In the episode of Family Guy titled "Da Boom" a costumed man warns Peter about the dangers of Y2K. Peter locks his family up in a bomb shelter on December 31, 1999. A nuclear holocaust occurs at the stroke of midnight, destroying much of Quahog and mutating or injuring many of the surviving citizens. The Griffins are free from mutations.
When food runs out, the family travels to Natick, Massachusetts, in hopes that the “Twinkee” (spelled “Twinkees” throughout the episode) factory survived. On the way, Stewie is exposed to nuclear waste and later mutates into an octopus-like creature. Upon their arrival at Natick, they establish a town, dubbed New Quahog, which Peter mismanages into chaos. Stewie begins to lay eggs.
Peter is eventually kicked out of the town he founded, and his family follows him, deciding where they should go next: a Carvel factory in Framingham, Massachusetts. Meanwhile, Stewie’s spawn hatch, and begin to kill the citizens.
The episode ends in a live-action parody of a famous episode of Dallas, where Pam Ewing wakes to find her husband Bobby in the shower. She tells him about the episode, which was apparently a dream, thus ret-conning the entire episode. This parody of the famous Dallas shower scene, where an entire previous season of Dallas was ret-conned as a dream.

--From the Family Guy Wiki

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